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Sufferers handled with flumazenil should be monitored for resedation, respiratory despair along with other residual benzodiazepine consequences for an proper interval right after treatment. Flumazenil will only reverse benzodiazepine-induced effects but will not likely reverse the consequences of other concomitant medicines. The reversal of benzodiazepine outcomes may very well be connected with the onset of seizures in sure high-possibility patients. The prescriber really should know about a threat of seizure in Affiliation with flumazenil therapy, specially in very long-expression benzodiazepine customers and in cyclic antidepressant overdose. The whole flumazenil package insert, including CONTRAINDICATIONS, WARNINGS and PRECAUTIONS, need to be consulted before use.
Although it can help many people, this medication could at times result in habit. This chance may be better When you've got a compound use dysfunction (including overuse of or dependancy to medication/Alcoholic beverages).
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Once you just take midazolam, you will be watched closely to make certain the drugs is Operating and will not lead to damaging Unintended effects.
Out of the blue stopping this medication could induce major (probably lethal) withdrawal, particularly when you have got utilized it for a long period or in high doses. To prevent withdrawal, your health practitioner may perhaps reduced your dose bit by bit.
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Drug interactions may well transform how your medications do the job or enhance your danger for severe Negative effects. This document will not contain all doable drug interactions.
Out of the blue stopping this medication may possibly bring about severe (probably fatal) withdrawal, especially if you have made use of it for a long time or in significant doses. To avoid withdrawal, your medical doctor may decrease your dose little by little.
Patient response to sedative brokers, and resultant respiratory status, is variable. Whatever the intended standard of sedation or route of administration, sedation can be a continuum; a patient may possibly transfer quickly from gentle to deep sedation, with probable lack of protecting reflexes.